Ans is c
t rna

Correct Answer - D
There is no stored fuel in the brain, but it utilized 60% of total energy
under resting conditions.
Glucose is virtually the sole fuel for the brain, except in prolonged
starving when ketone bodies are the major source.
Fatty acids do not serve as fuel for the brain, because they are
bound to albumin in plasma; hence cannot cross the blood-brain
barrier.

Correct Answer -D
Dopamine 8-hydroxylase is a 'copper' containing monooxygenase that requires ascorbic acid and molecular oxygen. It catalyzes the formation of norepinephrine

Correct Answer A option
-
The majority of gastric cancers are not hereditary, the mutations
identified in familial gastric cancer have provided important insights
into mechanism of carcinogenesis in sporadic cancers.
Germline mutations in CDHI, which encodes E cadherin, a protein
that contributes to epithelial intercellular adhesion are associated
with familial gastric cancers, which are usually of diffuse type.
Mutations in CDH 1 are present in about 50% of sporadic cases of
diffuse gastric cancers, while E cadherin expression is drastically
decreased in the rest, often by methylation of the CDH I promotor.
Lobular carcinoma of breast which also tends to infilterate as single
cells, & individuals with BRCA2 mutations are at increased risk of
developing diffuse gastric cancers

Non-competitive inhibition


• Inhibitor binds to adjacent site and not the
catalytic site of enzyme
◦ Catalytic property of enzyme is reduced:
decreased Vmax
• Affinity of the enzyme is not altered: Km is
unaltered

INICET 25 RECALL IN group @doctorusmle

Correct Answer - B
Ans. is 'b' i.e., Beta galactocerebrosidase

Correct Answer - C
The most common cause of albinism is a defect in tyrosinase, the enzyme most responsible
for the synthesis of melanin. Albinism is an inborn error due to lack of synthesis of melanin.
It is an autosomal recessive disorder with a frequency of 1 in 20,000


Ref: Textbook of Biochemistry and Human Biology by G. P.Talwar, 3rd Ed,Page 452

Correct Answer B
Ans. is 'b'i.e., Are lipid in nature
• Chaperones are proteins (not lipid).
Chaperones
• Certain proteins play a role in the assembly or proper folding of other
proteins without themselves being components of the latter.
• Such proteins are called molecular chaperones.
• Most chaperones exhibit ATPase activity and bind ADP and ATP
• This activity is important for their effect on folding
Some Properties of Chaperone Proteins
• Present in a wide range of species from bacteria to humans
• Many are so-called heat shock proteins (Hsp)
• Some are inducible by conditions that cause unfolding of newly
synthesized proteins (eg, elevated temperature and various
chemicals)
• They blind to predominantly hydrophobic regions of infolded proteins
and prevent their aggregation
• They act in part as a quality control or editing mechanism for
detecting misfolded or otherwise defective proteins
• Most chapersones show associated ATPase activity, with ATP or
ADP being involved in the protein-chaperone interaction
.| Found in various cellular compartments such as cytosol,
mitochondria, and the lumen of the endoplasmic reticulum