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✒️Write a scientific paper like a pro...

▶️Once per year!
▶️The first and the last Research week of this year!
▶️USERN Research Week
▶️USERN Summer Event
▶️August 24-29, 2019

✔️For more information and registration:
https://docs.google.com/forms/d/e/1FAIpQLSfRTbSIU15Lb9tkyPSacghOW_85EiWj0UHiU-sYeyfxHdzy7w/viewform

#Research

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Natural Killer Cells and Cancer Therapy, What We Know and Where We Are Going

💠New Paper by CIP

Natural killer (NK) cells are among the significant components of innate immune system and they have come to the first line of defense against tumor cells developing inside the body. CD56lo/CD16+ NK cells are highly cytotoxic and CD56hi NK cells can produce cytokines and perform a regulatory function. Specific features of NK cells have made them a unique choice for cancer immunotherapy. Simple interventions like cytokine-injection to boost the internal NK cells were the first trials to target these cells. Nowadays, many other types of intervention are under investigation, such as adoptive NK cell immunotherapy. In this paper, we will discuss the biology and function of NK cells in cancer immunosurveillance and therapeutic approaches against cancer via using NK cells.

https://www.futuremedicine.com/doi/full/10.2217/imt-2019-0040

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Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?

🌀New paper by CIP

Ovarian cancer is one of the most common causes of mortality throughout the world. Unfortunately, chemotherapy has failed to cure advanced cancers developing multidrug resistance (MDR). Moreover, it has critical side effects because of nonspecific toxicity. Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy. Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand systems. Nanoparticle-based codelivery of anticancer drugs and siRNA targeting various mechanisms of MDR is a cutting-edge strategy for ovarian cancer therapy, which is completely discussed in this review.


🌀https://www.futuremedicine.com/doi/full/10.2217/nnm-2018-0379

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Forwarded from USERN
🌏یوسرن و علم بدون مرز

⁉️چگونه علم بدون مرز به نفع همه ماست؟

سخنرانی تدکس دکتر نیما رضایی موسس و ریاست یوسرن در تدکس تهران 2019

مشاهده از طریق یوتیوب:
https://youtu.be/TtnEZUN8-bQ

مشاهده از طریق آپارات:
https://www.aparat.com/v/ICp1Y

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Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?

New paper by USERN interest groups

🌀Ovarian cancer is one of the most common causes of mortality throughout the world.

🌀Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy.

🌀Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand systems.

🌀Nanoparticle-based codelivery of anticancer drugs and siRNA targeting various mechanisms of MDR is a cutting-edge strategy for ovarian cancer.

To read the full paper:
https://www.futuremedicine.com/doi/abs/10.2217/nnm-2018-0379?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=nnm

#Paper

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Natural killer cells and cancer therapy, what we know and where we are going

New paper by USERN interest groups

🌀Natural killer (NK) cells are among the significant components of innate immune system and they have come to the first line of defense against tumor cells developing inside the body. CD56lo/CD16+ NK cells are highly cytotoxic and CD56hi NK cells can produce cytokines and perform a regulatory function.

🌀Specific features of NK cells have made them a unique choice for cancer immunotherapy.

🌀Simple interventions like cytokine-injection to boost the internal NK cells were the first trials to target these cells. Nowadays, many other types of intervention are under investigation, such as adoptive NK cell immunotherapy.

🌀Here,the biology and function of NK cells in cancer immunosurveillance and therapeutic approaches against cancer via using NK cells are discussed.

To read the full paper:
https://www.futuremedicine.com/doi/full/10.2217/imt-2019-0040

#Paper

@niima_usern
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Forwarded from USERN
USERN UEEE
🔴دیدار با پرفسور بهرام مبشر، استاد کیهانشناسی دانشگاه ریورساید کالیفرنیا
🕑 سه شنبه دوم مهرماه ساعت ۱۵-۱۳

📚نشست های UEEE با هدف آشنایی بیشتر دانشجویان و محققان جوان با دانشمندان برجسته پایه‌گذاری شده است. علاقه‌مندان می‌توانند در این گپ و گفت صمیمی تجربیات علمی و شخصی دانشمندان موفق را از زبان خودشان بشنوند و سوالات خود را مطرح کنند.

💡با توجه به محدود بودن ظرفیت، متقاضیان محترم با در نظر گرفتن ترتیب ثبت نام، و پس از بررسی انگیزه نامه با اولویت دانشجویان علوم پزشکی انتخاب خواهند شد:
https://forms.gle/9nkaCTAPKgmXCibu8

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Comparison of the effects of adipose tissue mesenchymal stromal cell-derived exosomes with conditioned media on neutrophil function and apoptosis

📑New Paper by CIP


📌Neutrophils have an important role in defending against pathogens by producing reactive oxygen species (ROS). Some studies suggest using multipotent mesenchymal stromal cells (MSCs) and MSC-conditioned media (MSC-CM) for increasing neutrophil's viability and function. But, there is no study on using MSC-derived exosomes for improving neutrophil's viability and function. So, we examined the effects of MSC-exosomes and also MSC-CM on neutrophil's function and survival and compared them with each other.

📌Exosomes and CM were isolated from human adipose tissue MSCs. Exosomes were characterized, and the protein content of them was determined. Neutrophils were isolated from five healthy donors, and the effects of the two independent treatments (exosomes and conditioned media) on neutrophil's apoptosis were measured by Annexin V-PI method, then neutrophil's function was evaluated using NBT and phagocytosis assays.

📌The conditioned media augmented neutrophil's phagocytosis and reactive oxygen species (ROS) production, but it couldn't decrease neutrophil's apoptosis.

📌This report showed that the use of MSC-exosomes and CM might be useful for increasing immunity by improving neutrophil's function and survival.

 https://www.ncbi.nlm.nih.gov/pubmed/31207404

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Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy

📑New Paper by CIP


📌 Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression.

📌However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the second is the apparent disagreement in the results of in-vitro and clinical studies that investigated ghrelin association to one type of cancer.

📌 In this study, we comprehensively reviewed in-vitro, in-vivo, and clinical studies and attempted to address local and systemic effects of ghrelin in (a) interpreting its summary clinical role in each cancer; (b) scrutinizing factors that regulate local effects of ghrelin and could justify different effects of ghrelin on different cancer cell-lines.


https://www.frontiersin.org/articles/10.3389/fonc.2019.01014/full


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Forwarded from USERN
🎇گردهمایی اهالی علم و هنر در چهارمین سالگرد تاسیس یوسرن

فرصتی برای دیدن، شنیدن و گفتن برای علاقه‌مندان به هنر و علم

در این برنامه شنونده سخنان:
💫 احسان رضایی (نویسنده)
💫 دکتر اذرخش مکری (استاد دانشگاه و روانپزشک)
💫 دکتر حمیدرضا نمازی (پزشك و استاد فلسفه علم و اخلاق)
💫 سیاوش صفاریان پور (چهره شناخته در حیطه ترویج علم)
💫 غزل مهدوی (روانشناس و ترانه سرای گروه دال)
و
💫 سروش صحت (کارگردان، نویسنده و مروج فرهنگ کتابخوانی)
خواهیم بود.

🎼🎤مهمان ویژه این برنامه گروه دال خواهد بود و قطعاتی را بصورت زنده اجرا خواهد کرد.

💠زمان : دهم دی ماه ۱۳۹۸، ساعت ۱۵

💠مکان: سالن شماره يک مرکز طبی کودکان، بلوار كشاورز، خيابان قريب، جنب بیمارستان امام خمینی

📍ثبت نام برای عموم آزاد است.

💠لینک ثبت نام اولیه:

https://bit.ly/2EjZ9EN

@usern_net
Forwarded from SICoMS
🛎Call for registration

SICoMS First Workshop:

Collaborating with foreign professors and universities

👨‍🏫Instructor: Prof. Nima Rezaei


👨‍🎓👩‍🎓Junior lecturers:

1️⃣Dr. Tohid Arastoo
2️⃣Dr. Elham Rayzan
3️⃣Dr. Mahsa Keshavarz


🗓Date: Thursday, January 9th (Dey 19th), 15:00-18:00

📍Venue: Students’ Scientific Research Center, Tehran

🗣Language: Persian

📄Certificates are provided by USERN and SICoMS

Deadline for registration: January 6th

♨️ For registration please click here


🆔@sicoms
🆔@usern_net
Prof. Nima Rezaei
The best national researcher of 2019


20th Abu Reyhan Biruni Research Festival
December 23rd, 2019
SBMU, Tehran

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Media is too big
VIEW IN TELEGRAM
🌐USERN
🌀at the dawn of the 5th year activity

🎥Interview of TV4 with Prof. Nima Rezaei, Founding President of USERN

#TV4
#Interview

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Forwarded from SICoMS
First SICoMS Workshop:
International Collaboration with Professors and Universities

👨‍🏫Instructor: Prof. Nima Rezaei

👨‍🎓👩‍🎓Junior lecturers:
1️⃣Dr. Tohid Arastoo
2️⃣Dr. Elham Rayzan
3️⃣Dr. Mahsa Keshavarz

🗓Date: Thursday, January 9th (Dey 19th), 15:00-18:00

📍Venue: Dr. Gharib Conference Hall, Children's Medical Center, Tehran (has been changed in order to permit more delegates to attend)

🗣Language: Persian

♨️ Schedule (Collaborate):
Communication: N. Rezaei / E. Rayzan (Scientific research collaboration)
Orientation: N. Rezaei
Liability: N. Rezaei
Limitation: N. Rezaei
Aims: N. Rezaei
Borders: N. Rezaei
Organization: N. Rezaei / T. Arastoo (Scientific exchange)
Reviewing: N. Rezaei / M. Keshavarz (Scientific co-publication)
Altruism: N. Rezaei
Time management: N. Rezaei
Ethics: N. Rezaei

Registration deadline: Jan 8th (extended)

🔹To register:
http://bit.ly/2QuaNDY

📩E-Mail: [email protected]

🆔@sicoms
🆔@usern_net
Forwarded from ASA
🌻 نخستین جشنواره بین المللی علم و هنر شبکه ی جهانی یوسرن 🌻

💜هنرمندان عزیز باید آثار خود را به نحوی طراحی کنند تا مخاطبین با دیدن آن اثر به یک پدیده ی علمی پی ببرند و به نحوی علم در آثار آنها به نمایش در بیاید. آثار هنرمندان عزیز باید تلفیقی از هنر آنها و علم باشد💜

🎭🎨🎬🎹🎻🚀🔮🧬🔬🦠🧲

👨‍👩‍👧‍👦رده ی سنی:
محدودیت سنی وجود ندارد.

👑جوایز:
نفر اول🥇: گرنتی به ارزش ۷۰ میلیون ریال
نفر دوم🥈: گرنتی به ارزش ۵۰ میلیون ریال
نفر سوم🥉: گرنتی به ارزش ۳۰ میلیون ریال

مهلت ارسال آثار:
۲۰ خرداد ۱۳۹۹

📨لینک ثبت نام و ارسال آثار:
https://docs.google.com/forms/d/1biRpQ7kr9GakIAF80jcAwHR2exMcm4xFWezav2wXjtY/prefill

برای اطلاعات بیشتر:
https://usern.tums.ac.ir/SiteContent/Show/asa

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@HealthAndArt
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USERN Miniature Talks

🔹New chance for juniors to present their artworks during USERN mTalks.

To apply:
http://shorturl.at/bktER

Deadline: Jan 30th

@USERN_mTalk
@niima_usern
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🔸New Paper by CIP

🔸The NLRP3 inflammasome: a therapeutic target for inflammation-associated cancers

https://www.tandfonline.com/doi/abs/10.1080/1744666X.2020.1713755

💬In this review, we discussed the biology and mechanism of NLRP3 inflammasome activation, its role in specific types of tumors and the novel therapeutic modalities targeting this complex.

🔻Fulltext available through:
🔻 https://www.tandfonline.com/eprint/6AGETFE6PIYYGHIMMQKP/full?target=10.1080/1744666X.2020.1713755

@cip_usern
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🔸New Book by USERN Interest Groups🔸

📚2nd edition of Cancer Immunology Book:

📕Volume 1, A Translational Medicine Context
has been published by Springer

🔻The 33-chapter book was drafted via International Scientific Networking and by contribution of World Leading Scientists in this field

🔻 https://www.springer.com/gp/book/9783030308445#aboutBook

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USERN Prize 2020

Application has started

USERN prize is an international award, established by USERN, which would be annually bestowed to junior scientists or researchers less than 40 years of age for any novel advancement or achievement in scientific education, research, or serving the humanity in five scientific fields including
🔹Medical sciences
🔹Biological sciences
🔹Formal sciences
🔹Physical-Chemical sciences
🔹and Social sciences.

🏅USERN Annual Awarding Festival: November 10th

⭕️Deadline for application: June 1st
https://usern.tums.ac.ir/Prize/ApplicationForm

⚜️For more information:
https://usern.tums.ac.ir/SiteContent/Show/PrizeFestival

#USERNPrize

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2025/07/14 10:25:48
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