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💥 CAR-macrophage, new hope for immunotherapic goals:

🔴 Immunotherapy is a method that developed on the basis of "tumor immune escape". In this method we manipulate the immune system to overcome the pathway of "tumor immune escape"

🟠 The current trend methods of immunotherapy are chimeric antigen receptor(CAR)-T cell therapy, immune checkpoint inhibitors(ICIs), and cancer vaccines.

🟡 Success in the field of CAR-T cell therapy has led researchers to develop their studies in the field of CAR-NK and CAR-macrophage (CAR-M) cells for tumor immunotherapy.

🟢 CAR-M makes a better opportunity for treating solid tumors. CAR-M is defined by modifying human macrophages with specific CARs to improve phagocytic activity and antigen presentation of macrophage against tumors. It refers to the transfer of the edited specific CAR gene into macrophage in order to equip them with the ability to bind to the tumor cell surface via specific antigen identification and subsequently activate macrophage activity against tumor cells.


📄 Reference: https://doi.org/10.1016/j.biopha.2021.111605

🆔 Follow us:
@Oncologylearn
@ResearchGroup1401

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1.3K viewsSep 21, 2024 at 18:52

💥 CAR-macrophage, new hope for immunotherapic goals:

🔴 Immunotherapy is a method that developed on the basis of "tumor immune escape". In this method we manipulate the immune system to overcome the pathway of "tumor immune escape"

🟠 The current trend methods of immunotherapy are chimeric antigen receptor(CAR)-T cell therapy, immune checkpoint inhibitors(ICIs), and cancer vaccines.

🟡 Success in the field of CAR-T cell therapy has led researchers to develop their studies in the field of CAR-NK and CAR-macrophage (CAR-M) cells for tumor immunotherapy.

🟢 CAR-M makes a better opportunity for treating solid tumors. CAR-M is defined by modifying human macrophages with specific CARs to improve phagocytic activity and antigen presentation of macrophage against tumors. It refers to the transfer of the edited specific CAR gene into macrophage in order to equip them with the ability to bind to the tumor cell surface via specific antigen identification and subsequently activate macrophage activity against tumor cells.


📄 Reference: https://doi.org/10.1016/j.biopha.2021.111605

🆔 Follow us:
@Oncologylearn
@ResearchGroup1401

BY Onco Learn