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Don't Eat Me!⛔️

🔴 Oneway for Don't eat me signal is an interaction between CD47 and SIRPalpha.
SIRP family has three different subtypes include Alpha, Beta, and Gamma.

🟠 In cancer cells interaction between SIRPalpha and CD inhibits macrophages to select cancer cells and macrophage phagocytosis and also this mechanism help cancer cells to evade the immunity.

🟡 Many studies shown that overexpression and higher levels of CD47 in tumor cells surface than non-malignant cells.

🟢 By exploiting the "Don't eat me" signal, cancer cells utilize CD47's overexpression to evade immune cell surveillance and clearance, making CD47 a potential target for novel anti-tumor therapies.

📄 Reference: https://doi.org/10.1016%2Fj.heliyon.2023.e20507

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Create: 2024-09-23
Last Update: 2024-12-29 03:17:06

Don't Eat Me!⛔️

🔴 Oneway for Don't eat me signal is an interaction between CD47 and SIRPalpha.
SIRP family has three different subtypes include Alpha, Beta, and Gamma.

🟠 In cancer cells interaction between SIRPalpha and CD inhibits macrophages to select cancer cells and macrophage phagocytosis and also this mechanism help cancer cells to evade the immunity.

🟡 Many studies shown that overexpression and higher levels of CD47 in tumor cells surface than non-malignant cells.

🟢 By exploiting the "Don't eat me" signal, cancer cells utilize CD47's overexpression to evade immune cell surveillance and clearance, making CD47 a potential target for novel anti-tumor therapies.

📄 Reference: https://doi.org/10.1016%2Fj.heliyon.2023.e20507

🆔 Follow us:
@Oncologylearn
@ResearchGroup1401

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Date: 2024-12-29|

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