tgoop.com/Pharmaceutical_diaries/3549
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معلومات حلوه اليوم😃
حول ال cephalosporins
اولاً
Some drugs can ? ⬆️ INR in patients taking warfarin
- do not use in patients who have a type 1 PCN allergy
Cefotetan can ⬆️ the risk of bleeding and cause a disulfiram-like reaction with alcohol ingestion
ضروري نتجنب استخدام مضادات الحموضه الضعيف مع 👇🏼 او نستخدمها بشكل منفصل ساعتين
Cefuroxime, cefpodoxime, cefdinir and cefditoren
السبب لنهن يقللون فعاليه المضادات الحيويه
بينما 👇🏼
H2RAs and PPIs should be avoided in use with
SIDE EFFECTS
Seizures (with accumulation), Gl upset, diarrhea, rash/allergic reactions/anaphylaxis, acute interstitial nephritis, myelosuppression with prolonged use,
? LFTs, drug fever, serious skin reactions (SJS/TEN)
MONITORING
Renal function, signs of anaphylaxis with 1st dose, CBC, LFTs
#ملاحظات
Ceftriaxone - no renal adjustment Cefixime available in a chewable tablet
Ceftazidime/avibactam covers some carbapenem-
resistant Enterobacteriaceae (CRE)
يوجد منهن عده أجيال وا بشكل فموي وا حقن
بنسبه للفمويه
1st Generation: Cephalexin
■ Common uses: skin infections (MSSA), strep throat
2nd Generation: Cefuroxime
■ Common uses: acute otitis media, community-acquired pneumonia (CAP), sinus infection (if an antibiotic is indicated)
3rd Generation: Cefdinir
■ Common uses: CAP, sinus infection (if an antibiotic is indicated)
بيمنا الحقن
1st Generation: Cefazolin
■ Common use: surgical prophylaxis
2nd Generation: Cefotetan and Cefoxitin
■ Anaerobic coverage (B. fragilis)
■ Common use: surgical prophylaxis (colorectal procedures)
■ Cefotetan can cause a disulfiram-like reaction with alcohol ingestion
3rd Generation: Ceftriaxone and Cefotaxime
■ Common uses: CAP, meningitis, spontaneous bacterial peritonitis, pyelonephritis
■ Ceftriaxone
□ No renal dose adjustment
□ Do not use ceftriaxone in neonates (age 0-28 days)
Ceftazidime (3rd Generation) and Cefepime (4th Generation)
■ Active against Pseudomonas
Ceftolozane/Tazobactam and Ceftazidime/Avibactam
■ Used for MDR Gram-negative organisms (including Pseudomonas) Ceftaroline
■ Only beta-lactam active against MRSA
BY يوميـ✨ـات صيدلانـيـ✨ــة
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