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Medicine@clinical P.387
CLINICAL Telegram 387



Natural History of Chronic Hepatitis D. Chronic hepatitis D is associated with a more rapid progression to cirrhosis and a higher risk of hepatocellular carcinoma than HBV monoinfection. Identifying patients in whom fibrosis progresses rapidly would be crucial for determining the prognosis, but mechanisms of fibrotic progression are poorly understood. Histologic findings (hematoxylin and eosin stain) are shown. Liver fibrosis is assessed with the use of Metavir staging, which ranges from F0 (no fibrosis) to F4 (cirrhosis). Some HDV genotypes may influence disease activity. Persistent HDV viremia is a factor in disease progression and a predictor of death. In liver disease in general, factors associated with fibrosis are male sex, older age at infection, excessive alcohol consumption, obesity, diabetes, and immunodeficiency.


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Natural History of Chronic Hepatitis D. Chronic hepatitis D is associated with a more rapid progression to cirrhosis and a higher risk of hepatocellular carcinoma than HBV monoinfection. Identifying patients in whom fibrosis progresses rapidly would be crucial for determining the prognosis, but mechanisms of fibrotic progression are poorly understood. Histologic findings (hematoxylin and eosin stain) are shown. Liver fibrosis is assessed with the use of Metavir staging, which ranges from F0 (no fibrosis) to F4 (cirrhosis). Some HDV genotypes may influence disease activity. Persistent HDV viremia is a factor in disease progression and a predictor of death. In liver disease in general, factors associated with fibrosis are male sex, older age at infection, excessive alcohol consumption, obesity, diabetes, and immunodeficiency.


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