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Buridan’s Assay and Nephrogenic Diabetes Insipidus.
In Buridan’s assay, a food- and water-restricted mouse is provided with two equally accessible reward spouts that contain liquid food in one and water in the other. Panels A and B are adapted from Richman et al.2 In Panel A, the “energy landscape” with wells for hunger and thirst represent a model explaining choice. If hunger and thirst are equal, the wells have equal depth and the initial choice between eating and drinking in this mouse model is random. As one urge starts to become satisfied, the landscape shifts, favoring the other urge; the mouse acts accordingly and alternates between drinking and eating until both urges are fully satisfied, as shown in Panel B. Richman et al. monitored the activity of mice deprived of food and water. After an olfactory cue, the mice could lick toward either food or water. The x axis in Panel B denotes trials across a session, and the y axis shows the cumulative number of licks after each olfactory cue.

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4.8K viewsMay 30, 2024 at 14:04

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Create: 2024-05-30
Last Update: 2025-01-29 03:52:29

Buridan’s Assay and Nephrogenic Diabetes Insipidus.
In Buridan’s assay, a food- and water-restricted mouse is provided with two equally accessible reward spouts that contain liquid food in one and water in the other. Panels A and B are adapted from Richman et al.2 In Panel A, the “energy landscape” with wells for hunger and thirst represent a model explaining choice. If hunger and thirst are equal, the wells have equal depth and the initial choice between eating and drinking in this mouse model is random. As one urge starts to become satisfied, the landscape shifts, favoring the other urge; the mouse acts accordingly and alternates between drinking and eating until both urges are fully satisfied, as shown in Panel B. Richman et al. monitored the activity of mice deprived of food and water. After an olfactory cue, the mice could lick toward either food or water. The x axis in Panel B denotes trials across a session, and the y axis shows the cumulative number of licks after each olfactory cue.

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